Sanguinaria canadensis plants are found growing in moist to dry woods and thickets, often on Flood plains and near shores or streams on slopes in Forests of South Kashmir. They grow less frequently in clearings and meadows or on dunes, and are rarely found in disturbed sites. Deer will feed on the plants in early spring. . Some bees come to collect pollen, including Mining Bees (Andrena), which are the most effective pollinators
Bloodroot is one of many plants whose seeds are spred by ants a process called Myrmecochory
Commercial uses of sanguinarine and bloodroot extract include dental hygiene products.The United States FDA has approved the inclusion of sanguinarine in toothpaste as an antibacterial or anti-plaque.